» ICSI means Intracytoplasmic Sperm Injection
» The technique was developed by Gianpiero Palermo at Brussels University.
» The first successful birth by ICSI took place 1992
Every woman is born with a fixed number of eggs. As the age advances the number of eggs decreases. Hence leading to difficulty in conception especially after 35 years of age. In such conditions the options available are donor egg ( from another woman ) or stem cell therapy. The success rate of stem cell therapy is more than 50 percent .
Stem cells are cells which have
» Ability of unlimited self renewal
» Ability of differentiation (to give rise to a specialised cell type that becomes part of a healthy person)
Multipotent stem cells can be harvested from bone marrow of the patient
The stem cells are generally classified into various categories. Some of these are as follows –
» Embryonic
» Non-Embryonic
» Induced Pluripotent
There are several specific technologies, which can be used in stem cell treatment. Some of them are –
» Suspension Technology
» Inhibitor Differentiation Method:
Cases of INFERTILITY with
» Premature ovarian failure ( inability of a woman to form eggs )
» Testicular failure ( inability of a male to form sperms )
» Ashermans syndrome ( Uterine Synechia- when walls of the uterine cavity stick to each other compromising the cavity space )
The success rate of stem cell therapy is variable , it can be up to 50 percent.
Stem cell preparation is injected laparoscopically into the ovary. American studies have shown increase in ovarian size and 2 fold increase in estrogen levels ( female hormone levels ) up to 1 year after the procedure .
Relief in symptoms of POF such as hot flushes , night sweats decreased libido , vaginal dryness , repeated Urinary infections has been seen leading to enhanced quality of life.